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KMID : 0603820080140010059
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Journal of Experimental & Biomedical Science
2008 Volume.14 No. 1 p.59 ~ p.62
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Expression of Endoplasmic Reticulum Membrane Kinases by Thyroid Stimulating Hormone in the FRTL-5 Cells
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Jin Cho-Yi
Kwon Ki-Sang
Goo Tae-Won
Kwon O-Yu
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Abstract
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This experiment was performed to study the effect of TSH (thyroid-stimulating hormone) on the expression of endoplasmic reticulum (ER) chaperones in the rat thyrocytes FRTL-5 cells. Although the expressions of ER membrane kinases (ATF6, IRE1 and PERK) were specially enhanced under absence of TSH, no remarkable up- or down regulations of ER chaperones (BiP, CHOP and Calnexin) were detected by TSH. We firstly report here that TSH by dose up-regulated expression of ER membrane kinases in FRTL-5 culture thyrocytes.
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KEYWORD
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Endoplasmic reticulum (ER), ER molecular chaperone, Thyroid-stimulating hormone (TSH), ER membrane kinases, FRTL-5 cells
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